Pathophysiology of NAFLD

  • Research type

    Research Study

  • Full title

    Investigating the role of inflammation and Oxidative stress damage in Non-Alcoholic Fatty Liver Disease

  • IRAS ID

    228919

  • Contact name

    Jacob George

  • Contact email

    j.george@dundee.ac.uk

  • Sponsor organisation

    University of Dundee

  • Duration of Study in the UK

    0 years, 1 months, 7 days

  • Research summary

    Non-Alcoholic Fatty Liver Disease (NAFLD) has been observed in 25-33% of the European population and it is the commonest cause of liver disease in this population. Furthermore, with an increasing number of people with Chronic Liver Disease and high levels of obesity in Scotland, NAFLD presents a major healthcare burden. We aim to take a single blood sample from patients attending the Tayside NAFLD clinic to measure markers of inflammation and oxidative stress. The patients involvement ends after the blood sample is given. We will collect fully anonymised (NOT linked anonymised) clinical data, demographic and biometric data from the patients clinical notes. The aim is to investigate if there is evidence of liver inflammation and oxidative stress in patients with NAFLD and if they correlate with severity of disease. This will help us understand how to target treatments for NAFLD in the future

  • REC name

    East Midlands - Leicester South Research Ethics Committee

  • REC reference

    17/EM/0213

  • Date of REC Opinion

    9 Jun 2017

  • REC opinion

    Further Information Favourable Opinion