Patellofemoral dislocation in Charcot Marie Tooth disease

  • Research type

    Research Study

  • Full title

    Incidence and risk of patellofemoral dislocation in people with Charcot-Marie-Tooth disease (CMT)

  • IRAS ID

    252823

  • Contact name

    Vanshree Patel

  • Contact email

    research.governance@gosh.nhs.uk

  • Sponsor organisation

    UCL Great Ormond Street Institute of Child Health

  • Duration of Study in the UK

    0 years, 5 months, 1 days

  • Research summary

    The purpose of this study is to learn more about the number of adults living with Charcot Marie Tooth Disease (CMT) who experience patella dislocation (where the kneecap moves out of its normal position) as part of their condition. Clinicians working with people with CMT report that patellar dislocation appears to be more common than would be expected in people of a similar age without CMT and would like to know if this is the case. In addition to learning about the number of people this might affect, the work will also explore any factors which may lead to a greater risk of dislocation. To date, only one small study has looked at the frequency of patellar dislocation, but this was in children only. This work will build on this by looking at an adult population. By understanding more about this disorder the aim is for the management of people with CMT to continue to be improved.
    This is an observational study that will allow for the quantification of how many adults with CMT attending the MRC Centre for Neuromuscular Disease at NHNN from February to July 2019 either present with, or report a history of patellar dislocation and to observe any predisposing features. All of those patients attending their routine clinic appointment during this time period who are over 18 years old and have a definite diagnosis of CMT will be invited to take part. Participation will involve: having a structured examination of the joints of the legs, especially the knee, to establish strength of the leg muscles, range of movement of the joints and their sensation. Questions about any difficulties with the knee joints, particularly the kneecaps, will also be asked. The study will be sponsored by UCL GOSICH as the researcher is an MSc student of that Institute.

  • REC name

    HSC REC A

  • REC reference

    19/NI/0031

  • Date of REC Opinion

    25 Feb 2019

  • REC opinion

    Further Information Favourable Opinion