PASSPORT-1
Research type
Research Study
Full title
Penicillin Allergy delabelling in Surgical preaSsement – Patient outcomes and Risk stratification Tools (PASSPORT-1): Diagnostic accuracy of the risk stratification of penicillin allergy histories by non-specialists working in the peri-operative setting
IRAS ID
313986
Contact name
Louise Savic
Contact email
Sponsor organisation
Leeds Teaching Hospitals NHS Trust Research and Innovation Dept
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Penicillin antibiotics are a safe and effective way of treating a broad range of infections. However, it is very common to carry a label of penicillin allergy, which prevents patients from having penicillin antibiotics when they need them. This can have potentially serious consequences, such as increased risk of ‘super-bug’ infections longer hospital stays, and more chance of developing a wound infection after surgery. Fewer than 1 in 10 people labelled ‘penicillin allergy’ actually are allergic when tested. Incorrect allergy labels have usually been given because of common side effects of penicillin such as stomach upset, or because the infection for which penicillin was being used caused a rash. Patients can be tested to see if their allergy label is really true but this requires an allergy specialist and unfortunately we don’t have enough specialists to deal with this very common problem. Previous studies around the world have shown that with the right training, non-allergy specialists can perform an allergy assessment within the surgical setting.
In this study 100 patients will be recruited to evaluate the diagnostic accuracy of a penicillin allergy test in the hands of a doctor or nurse making preparations for your surgery when compared with the 'gold-standard' test performed by specialist doctors in allergy medicine, in patients with a penicillin allergy label. In addition interviews will be conducted with patients and the healthcare professionals to explore their experiences of using the assessment. This study will be the first step to understanding how well such pathways might perform in the future.
REC name
North West - Preston Research Ethics Committee
REC reference
22/NW/0174
Date of REC Opinion
22 Sep 2022
REC opinion
Further Information Favourable Opinion