PARTNER Study (hyPertension After coaRcTatioN rEpaiR)
Research type
Research Study
Full title
Why do children develop hypertension after coarctation repair?
IRAS ID
318070
Contact name
Michael A Quail
Contact email
Sponsor organisation
UCL
Clinicaltrials.gov Identifier
Z6364106/2022/08/61, UCL Data Protection Registration Number
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
In coarctation of the aorta, there is a narrowing in the aorta just beyond the branches that supply the head and arms with blood. This prevents the blood from circulating normally in the lower half of the body and can be very serious. The narrowing of the aorta is usually repaired with surgery during early childhood.
In the long-term, up to 60% of patients who have had a coarctation repair develop high blood pressure, and this begins in childhood. High blood pressure can cause problems in later life, including strokes (damage to the brain from bleeding or clots) and heart failure (the heart muscle doesn't squeeze and relax properly).
We would like to understand why high blood pressure develops by studying children after their operation and following them as they grow up. We will use MRI scans and blood tests to try and understand this.
Our hope is to understand the causes of hypertension and that this knowledge will help develop better treatments for high blood pressure and improve the lives of patients with coarctation.
REC name
London - Brighton & Sussex Research Ethics Committee
REC reference
23/PR/0097
Date of REC Opinion
21 Mar 2023
REC opinion
Further Information Favourable Opinion