Paradoxical Lucidity in Severe End-Stage Dementia
Research type
Research Study
Full title
Paradoxical Lucidity in Severe End-Stage Dementia: A Mixed Method Prospective Study
IRAS ID
336800
Contact name
Natalia Leontovich
Contact email
Sponsor organisation
NYU Langone Health
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Cognitive decline in dementia is considered irreversible; however, episodes of paradoxical lucidity (PL) in severe dementia suggest other mechanisms may be in play. Beyond anecdotal reports of transient PL events occurring in patients predominantly in late-stage dementia and typically lasting anywhere from a few minutes to several hours, we know little about PL. We propose to develop and conduct a mixed methods prospective study of PL during end stage advanced dementia, creating a definition and measurement scale for PL in advanced dementia, and identifying the potential electro cortical biomarkers of PL in advanced dementia.
REC name
Wales REC 1
REC reference
24/WA/0099
Date of REC Opinion
17 Apr 2024
REC opinion
Unfavourable Opinion