Paracetamol effect on the feeling of breathing in subjects with colds

• Research type

  Research Study

• Full title

  To assess the subjective effect of two paracetamol preparations on the feeling of breathing in subjects with the common cold.

• IRAS ID

  59174

• Contact name

  Miss Suhair Jawad

• Sponsor organisation

  Glaxosmithkline Consumer Healthcare

• Eudract number

  2010-021798-34

• ISRCTN Number

  1

• Research summary

  The common cold is one of the most common human infections, with 100 million colds annually in the USA. Colds are virtually never fatal and are rarely complicated by more serious infections, but they exact a tremendous toll in morbidity and economic cost. Clinical features of upper respiratory tract infection (common cold and flunza) include headache, fever, nasal, pharyngeal; lower respiratory tract and constitutional symptoms. Paracetamol has been shown to be more effective than placebo in treating symptoms associated with upper respiratory tract infection; sore throat and fever. Menthol is often added to products for sufferers of cold anfluas it provides a pleasant sensation of increased nasal airflow. This current mentholated paracetamol hot drink combines paracetamol in a hot drink formulation with the added benefit of the menthol in the flavour system for perception of increased airflow. The aim of this study is to evaluate the degree to which this formulation will provide perception of relief of symptoms.

• REC name

  Wales REC 1

• REC reference

  10/WSE04/45

• Date of REC Opinion

  11 Sep 2010

• REC opinion

  Favourable Opinion