PANDA: Pregnancy And chronic hypertension: NifeDipine or lAbetalol
Research type
Research Study
Full title
Pregnancy And chronic hypertension: NifeDipine or labetalol as Antihypertensive treatment
IRAS ID
135284
Contact name
Lucy Chappell
Contact email
Sponsor organisation
King's College London
Eudract number
2013-003144-23
ISRCTN Number
n/a
Clinicaltrials.gov Identifier
n/a
Research summary
Around 3% of pregnant women have raised blood pressure before they
become pregnant. These women are more likely to develop serious
complications including pre-eclampsia (complicated high blood pressure in
pregnancy), stroke, bleeding in the brain, the placenta separating from the
wall of the womb and even dying in pregnancy. They may also have
babies who are underweight and born early. The chances of the baby dying
in the womb or shortly after birth are also higher. Premature and small
babies may have immediate health problems including breathing and
feeding difficulties, as well as long term health problems including high blood
pressure and kidney disease.Good control of blood pressure in pregnancy can prevent these problems,
including reducing the risk of bleeding into the mother’s brain. A recent UK
report identified bleeding in the brain as a leading cause of deaths related to
pregnancy that could be prevented.Currently doctors are not sure which is the best blood pressure tablet to give
pregnant women with raised blood pressure before pregnancy. We wish to
do a study in 114 pregnant women to compare two frequently used blood
pressure lowering drugs to help us plan a bigger trial in many centres
around the UK. We want to find out which tablets are best at keeping the
blood pressure down in pregnancy, without any harmful effects on the health
of the mother or baby. We will also ask women whether they can take the
tablets in the right dose without having side-effects.In women who are not pregnant the choice of drug for raised blood pressure
depends partly on ethnic background; in African/ Caribbean women this can
be due to the way their bodies process salt. Our proposed study is also
looking at which drugs might work best in pregnant women of varying ethnic
backgrounds.REC name
East of England - Cambridge East Research Ethics Committee
REC reference
13/EE/0390
Date of REC Opinion
3 Feb 2014
REC opinion
Further Information Favourable Opinion