Pain and quality of life in patients with PLO
Research type
Research Study
Full title
Pain and quality of life in patients with pregnancy and lactation induced osteoporosis: A case-control study of real- life clinical practice
IRAS ID
327945
Contact name
Richard Keen
Contact email
Sponsor organisation
Research and Innovation Department, RNOH
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Pregnancy and lactation associated osteoporosis (PLO) is a rare, but severe form of osteoporosis which is characterised by a reduction in bone mineral density (BMD) and occurrence of fragility fractures during the last trimester of pregnancy or during lactation.
Despite the severe physical and psychological consequences of PLO, there is no prospective data on clinical symptoms and quality of life and associations with BMD recovery. Therefore, this study addresses this unmet need to investigate improvements in short term qualitative outcomes including pain, disability and quality of life and associations with BMD recovery.
PLO patients who receive standard (usual) care at the Royal National Orthopaedic Hospital (RNOH) will be recruited to the study and their changes in pain, disability and quality of live over period of 12 months will be assessed through the use of questionnaires. Healthy women who have had a baby and do not have PLO will also be included in the study as a comparison group. This group will allow for the assessment of fluctuations in pain, disability, and changes in quality of life that may occur in women around the time of pregnancy. The non- PLO participants will be matched with the PLO group based on relevant demographic characteristics.REC name
North West - Greater Manchester South Research Ethics Committee
REC reference
23/NW/0254
Date of REC Opinion
12 Oct 2023
REC opinion
Further Information Favourable Opinion