Paediatric TracheBiome 2
Research type
Research Study
Full title
Investigating defence against airway infection in children with and without tracheostomies – the paediatric tracheBiome study 2
IRAS ID
328238
Contact name
Jason Powell
Contact email
Sponsor organisation
Newcastle upon Tyne Hospital NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 31 days
Research summary
Many children who have serious medical problems require help with their breathing long-term. A life-saving procedure in this setting involves a surgeon making a small hole in the windpipe. This procedure (“tracheostomy”) is often long-term and carries a high risk of complications and in particular lung infections that can cause multiple re-admissions to hospital and can themselves be life-threatening. The precise ways in which tracheostomy promotes infection are unknown in children, but our previous work suggested clues from studying the airways of tracheostomised children. We therefore want to investigate this further, in more children, in a more detailed way, how complications might arise in the child's windpipe, with a view to developing better preventive strategies in the future. We aim to investigate how the windpipe’s immune system works before and after a tracheostomy procedure. By carrying out this research we aim to identify potential new treatments that may reduce the number of breathing problems that these children face.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
23/WM/0131
Date of REC Opinion
3 Jul 2023
REC opinion
Further Information Favourable Opinion