Paediatric Neuroendocrine Cancers
Research type
Research Study
Full title
A retrospective single institution study of children and young people treated with surgery and/or molecular radiotherapy for adult-type neuroendocrine cancers to describe the patient and disease characteristics, treatment and outcome.
IRAS ID
331942
Contact name
Mark Gaze
Contact email
Sponsor organisation
University College London Hospitals
Duration of Study in the UK
0 years, 3 months, 31 days
Research summary
Adult type neuroendocrine tumours are a diverse group including paraganglioma, phaeochromocytoma, carcinoid and insulinoma. They are very uncommon in children and young people. Localised disease may be managed by surgery alone, but metastatic disease may require medical treatments or molecular radiotherapy. There have been no published clinical trials of this disease group in the childhood age group. This is a non-interventional, retrospective service evaluation, using routinely collected standard of care data. The purpose of this study is to create a descriptive account of all patients with these tumour types aged less than 25 at presentation treated in one institution. Patients will be identified from departmental records. Data including demographic and clinical details, extent of disease as shown by imaging and biochemical investigations, treatments administered, response to treatment and survival will be collected. Data will be anonymised and analysed, and descriptive papers written. The aim is to identify the natural history of these cancers, to identify management strategies which might be generalisable to guide future practice, and to identify uncertainties which in the future, be addressed in a prospective clinical trial.
REC name
London - Bromley Research Ethics Committee
REC reference
23/LO/0843
Date of REC Opinion
28 Sep 2023
REC opinion
Favourable Opinion