Oxygen-enhanced MRI and filtration fraction in chronic kidney disease
Research type
Research Study
Full title
Renal magnetic resonance imaging with oxygen-enhancement and derived filtration fraction as novel biomarkers of progression of chronic kidney disease
IRAS ID
179108
Contact name
Aghogho Odudu
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
1 years, 3 months, 31 days
Research summary
Damage to the small blood vessels within the kidney (diabetic nephropathy) is a common complication of diabetes and is the leading cause of end-stage kidney disease in the United Kingdom. Diabetes damages the kidney by altering filtering function and reducing oxygen levels. New ways of measuring the filtering function and kidney oxygen levels might help to test the severity of kidney disease due to diabetes. We wish to test the practicality and reliability of a new way of measuring oxygen and blood flow in the kidney called Oxygen-Enhanced Magnetic Resonance Imaging (MRI). This does not require any x-rays or radiation, is quick and painless and uses breathing of high doses of oxygen or plain room air to make pictures of the kidney showing blood flow and oxygen levels. Thirty-two study participants will undergo an Oxygen-Enhanced MRI scan of the kidneys. This will be compared and combined with existing gold-standard techniques including a test which uses radioactive markers and carries a small dose of radiation. The study takes place on two half-days over 2 weeks. The study is being carried out by Dr Aghogho Odudu, NIHR Clinical Lecturer in Renal Medicine in partnership with staff from the Salford Royal Hospital, Manchester Royal Infirmary, University of Manchester and Wellcome Trust Clinical Research Facility. The study is being funded by the renal research fund of Salford Royal Hospitals NHS Foundation Trust and a University of Manchester MRI facilities grant.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
15/NW/0817
Date of REC Opinion
12 Nov 2015
REC opinion
Further Information Favourable Opinion