Ovarian Cancer Plasmajet study

• Research type

  Research Study

• Full title

  A Comparison of the Clinical and Histological appearances after treatment of Ovarian Cancer with Plasmajet

• IRAS ID

  241870

• Contact name

  Robert Macdonald

• Contact email

  Robert.macdonald@lwh.nhs.uk

• Sponsor organisation

  Liverpool Women's NHS Foundation Trust

• Duration of Study in the UK

  0 years, 2 months, days

• Research summary

  Why - Ovarian cancer standard treatment is to offer a combination of surgery and chemotherapy, and the surgical intent aims for no residual disease at the end of the operation. This usually involves removal of the Gynaecological organs, but also other involved sites such as bowel, spleen, lymph nodes and peritoneum which increases the risk of complications and morbidity.
  What - Plasmajet may have a role in reducing the morbidity from ovarian cancer surgery, with studies showing reduced thermal damage and bowel trauma compared to other surgical means, and it has been used clinically in ovarian cancer surgery. However there have been no published studies comparing the clinical and histological appearances following treatment with Plasmajet.
  The aim of this study is to assess the clinical appearances of tissue following treatment with Plasmajet, and to compare this with the histological assessment.
  Who and Where- Women presenting to the Liverpool Womens Hospital (a tertiary referral Gynae Oncology Centre) with a clinical or histological diagnosis of ovarian cancer who are due to undergo surgery following MDT discussion and agreement. At surgery, a portion of tissue removed as part of the standard ovarian surgery will be marked for identification then treated with Plasmajet to clinically remove all ovarian cancer tissue. The area will then be reviewed by Gynaecological Pathologists to assess whether
  1. Any ovarian tumour is still identifiable, and
  2. If any trauma to the underlying structure is present

• REC name

  Yorkshire & The Humber - Sheffield Research Ethics Committee

• REC reference

  18/YH/0455

• Date of REC Opinion

  14 Dec 2018

• REC opinion

  Further Information Favourable Opinion