Outcomes of periodontal regenerative treatment
Research type
Research Study
Full title
Short & medium term outcomes of periodontal regenerative procedures. A two-part study with a) analysis of periodontal records of a cohort of periodontitis patients and b) a single visit recall and comprehensive periodontal re-evaluation.
IRAS ID
280800
Contact name
Nikolaos Gkranias
Contact email
Sponsor organisation
Queen Mary University of London
Duration of Study in the UK
1 years, 3 months, 1 days
Research summary
Gum disease is a disease that leads to tooth loss and is caused by bacteria that accumulate at the gum line.
Its treatment aims at stopping disease progression and includes oral hygiene instructions, deep cleaning and gum surgery. In some cases, depending on the local anatomy of defects dentists can attempt to “regenerate”/regrow some of the lost tissues using either biomaterials or specific surgical flaps.
Previous studies have shown that regenerative gum surgery can be successful and have confirmed this treatment as the treatment of choice for specific defects. However, these results come from clinical studies where ideal conditions and very experienced surgeons are involved. Nevertheless the success rate of regenerative procedures performed by specialists in training in a NHS Teaching Hospital is not known .
The aim of this study is to check the results of regenerative surgery and factors influencing its success/failure in patients with gum disease treated in a UK secondary care setting.
A cohort of patients that underwent periodontal regenerative treatment at Barts Royal London Dental Hospital (RLDH) between January 2017 and January 2019 will be the study population.
The study will have two parts:
PART 1: An initial study looking back at clinical data of patients that received gum surgeries at the Royal London Dental Hospital with the goal of defining treatment’s success over a short time period.
PART 2: A study in which patients identified through PART 1 will be invited to participate to one visit for a gum check-up to assess success of previous gum surgery treatment over a longer time period.
The data collected through part 1 and 2 of the study will allow to assess changes over time of the gum health in order to establish success / failure of the regenerative procedure and analyse factors influencing that.REC name
London - Bloomsbury Research Ethics Committee
REC reference
21/LO/0092
Date of REC Opinion
12 Mar 2021
REC opinion
Further Information Favourable Opinion