Outcomes after surgery for congenital cataract
Research type
Research Study
Full title
Mechanisms underlying visual outcomes and glaucoma after surgery for congenital/infantile cataract
IRAS ID
187735
Contact name
Annegret Dahlmann-Noor
Contact email
Sponsor organisation
Moorfeilds Eye Hopsital NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Poor vision remains a problem in children born with bilateral cataract; in those with unilateral cataract, vision in the affected eye also often is poor. Early cataract surgery is often complicated by optic nerve damage from glaucoma and development of nystagmus. The risk of glaucoma appears highest if surgery is carried out within the first few weeks of life, whereas the risk of nystagmus and poor foveation is highest with delayed cataract surgery. The mechanisms underlying the development of glaucoma and nystagmus after congenital cataract surgery are not known; factors such as maturation of the iridocorneal drainage angle and fovea have not been explored.
The present study will systematically explore the development of these structures and visual function in children age 0 to 16 years with a history of cataract surgery, and a group of age-matched children with structurally healthy eyes. We will acquire high-resolution anterior and posterior segment optical coherence tomography images, measure axial length by ultrasound, and carry out eye waveform readings, to determine whether the growth of the eye is impaired after lensectomy, increasing the risk of glaucoma.REC name
London - Stanmore Research Ethics Committee
REC reference
16/LO/0327
Date of REC Opinion
8 Apr 2016
REC opinion
Further Information Favourable Opinion