Outcome prediction in neonatal hypoxic-ischaemic enceophalopathy (HIE)
Research type
Research Study
Full title
Southampton Neurodevelopmental Follow-up programme - Early assessments of brain structure and function and associations with neurodevelopmental outcomes in children with neonatal hypoxic-ischaemic encephalopathy (HIE) – Secondary data analysis
IRAS ID
278072
Contact name
Brigitte Vollmer
Contact email
Sponsor organisation
University Hospital Southampton NHS Foundation Trust
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Neonatal hypoxic-ischaemic encephalopathy (HIE) remains a significant problem with a high proportion of surviving infants developing neuromotor, cognitive, and/or behavioural difficulties later in life, despite the introduction of hypothermia treatment. It is important to identify problems early so that families can be supported and early intervention started.However, most follow-up programmes only assess whether severe neuromotor impairment (cerebral palsy, CP), and/or global cognitive impairment are present as these children get older. Furthermore, although evidence is growing, there is still limited evidence on the predictive value of early neuroimaging, EEG, and serial neurological assessments.
In Southampton we have set up a standardised clinical follow-up (FU) programme with comprehensive assessment, at developmentally meaningful time points (term age, age 3 months,12 months,24 months), including the domains of neurology (including minor neurological dysfunction), cognitive development, different aspects of behaviour, and health status. It also includes early assessments of brain injury (neuroimaging, MRI)), brain function (EEG) to improve outcome prediction at an early stage. This protocol is based on evidence from existing studies, and we would now like to examine our clinical data in the Southampton cohort, to (1) investigate specifically 2 year outcomes in the Southampton patients; (2) investigate how useful the tools we use in the clinical follow-up programme are for prediction of outcome at age 1 and 2 years.All infants admitted to Princess Anne Hospital, University Hospital NHS Foundation Trust, for treatment of HIE are enrolled in the standardised clinical FU programme and data are recorded in our clinical data base. We would like to use existing clinical data from the infants born between 05.08.2009 – 31.12.2017. All patient identifying information will be removed prior to the data being analysed by the researchers. Patients/Families of patients will not be contacted and no new information in addition to the existing clinical information will be collected.
REC name
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REC reference
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