Outcome prediction following CPET and colorectal surgery
Research type
Research Study
Full title
Cardiopulmonary exercise variables are associated with postoperative morbidity after major colorectal surgery - A validation study
IRAS ID
159211
Contact name
Malcolm West
Contact email
Sponsor organisation
Aintree University Hospitals NHS Foundation Trust
Research summary
Major colorectal surgery carries substantial risk of complications (up to 50%) and death, particularly in elderly patients and those with medical problems. Outcome after major surgery depends on modifiable factors such as the medical care received before, during and after surgery, as well as the tolerance of surgical trauma by the body. Accurate risk stratification permits modification of preoperative patient status as well as optimisation of intra- and postoperative management, and thus facilitates efficient use of hospital resources (e.g. intensive care and ward beds), and enhances shared decision-making.
Cardiopulmonary exercise testing (CPET) has been used for risk stratification before in thoracic and abdominal surgery. This tests the cardiorespiratory reserve (physical fitness) at rest and under the stress of maximal exercise (mimicking that of major surgery), and is the most objective and precise means of evaluating pre-surgical fitness.
This present study attempts to analyse pooled anonymized clinical data from 7 major colorectal units in the UK who perform pre-operative CPET as part of routine patient care. This study will be used in an attempt to validate the relationship between CPET derived variables and short term post-operative outcomes after major colorectal surgery which has been shown by our group in one NHS institution(“Cardiopulmonary exercise variables are associated with postoperative morbidity after major colonic surgery – a prospective blinded observational study” (Br J Anesthesia 2014;112(4):665-71).We aim to recruit 500 patients who will undergo a CPET, elective colorectal surgery and post-operative follow-up.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
14/EM/1038
Date of REC Opinion
23 Jun 2014
REC opinion
Favourable Opinion