Outcome following SAH

• Research type

  Research Study

• Full title

  What are the important factors in determining outcome following Subarachnoid haemorrhage (SAH)?

• IRAS ID

  105155

• Contact name

  Hiren Patel

• Contact email

  hiren.patel@srft.nhs.uk

• Sponsor organisation

  University of Manchester

• Research summary

  SAH occurs when a blood vessel on the surface of the brain ruptures. Half of all SAH are caused by an aneurysm (bulge) on a blood vessel. Only 30% of patients with aSAH survive long enough to make it to hospital; and of those who survive, 50% may have long term disability. SAH is treated by preventing the aneurysm from rebleeding either by surgical application of a clip around the neck or by packing it with tiny titanium coils, inserted into the blood vessels of the brain via a catheter. Both these treatments carry a risk of stroke, infection or re-bleed.

  Factors affecting recovery from aSAH include;
  i) Rebleeding from the aneurysm whilst awaiting treatment.
  ii) Delayed stroke – Occurs in up to 25% of patients between 3-21 days after SAH and which may cause long term disability.
  iii) Increased pressure inside the brain caused by excess fluid in the brain (hydrocephalus). This is treated by insertion of drain; either temporary or permanently.
  iv) Infection

  This study aims to improve the care and outcome for patients with SAH. As part of service development, data is collected on patients admitted with aSAH to Greater Manchester Neuroscience Centre (GMNC and by using this data to explore the clinical characteristics, investigations and management of patients admitted to GMNC between 01/01/2005 to 01/01/2015, we will be able to:
  i)assess the patient outcomes (recovery/level of disability),
  ii)determine the impact of changes in treatment plans,
  iii)assess the affect that other illness/conditions have on outcome,
  iv) assess whether outcome can be predicted using brain imaging and
  v) determine whether there are gender differences which may affect outcome in patients with aSAH.
  This will inform continuing improvements in the care of patients following aSAH

• REC name

  East Midlands - Leicester Central Research Ethics Committee

• REC reference

  13/EM/0419

• Date of REC Opinion

  1 Nov 2013

• REC opinion

  Favourable Opinion