ORISE Gel
Research type
Research Study
Full title
ORISE Study: Evaluation of novel injecting solution (ORISE) during endoscopic resection of colorectal polyps.
IRAS ID
275810
Contact name
Dr Alice Mortlock
Contact email
Sponsor organisation
Portsmouth Hospitals University NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Bowel cancer is the third most common cancer in the UK. It develops through growths in the bowel called polyps. With recent advancements in technology, early cancers can be found and removed through endoscopic techniques and hence avoiding surgery. The current techniques in use are Endoscopic mucosal resection (EMR) or endoscopic submucosal dissection (ESD). Both the above procedures require an injection of a fluid to the base of the lesion which lifts it up hence leading to a safer resection (avoids making holes in the bowel- perforation). The most common injection used currently is a mixture of saline, adrenaline and a dye. Although cheap and readily available, this solution tends to dissipate away from the tissue very quickly, hence potentiating the need of multiple injections during the procedure. This not only increases the time of the procedure, but also impairs the field of endoscopic vision and increases the rate of complication.
ORISE gel is a new injecting solution which is poloxamer based. The advantage of this solution is that it lasts in the tissue for much longer than saline, hence reducing number of injections ( possible one injection for the entire procedure) This reduces the length of the procedure and the complications associated with it.
We aim to study the efficacy and feasibility of ORISE gel in endoscopic resection of lower gastrointestinal polyps.
REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
20/YH/0343
Date of REC Opinion
28 Jan 2021
REC opinion
Further Information Favourable Opinion