Organising Pneumonia in Connective Tissue Disease
Research type
Research Study
Full title
Imaging Appearances of Organising Pnuemonia/NSIP in Connective Tissue Diseases
IRAS ID
277904
Contact name
Anand Devaraj
Contact email
Sponsor organisation
Royal Brompton Hospital NHS trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Anti-synthetase (and similar connective tissue) syndromes are rare diseases that are associated with a pulmonary condition called 'organising pneumonia' (OP). In this cohort of patients, OP can present either as a progressive disease with poor prognosis, or can resolve in its entirety. To date, the imaging features of OP in anti-synthetase (and similar connective tissue) diseases has not been explored and there has been no evaluation of imaging features that may predict prognosis.
We propose to examine the HRCTs (High Resolution CTs) of a cohort of patients with clinically defined anti-synthetase syndrome and other connective tissue diseases at a large tertiary referral centre (Royal Brompton Hospital).
Consecutive patients who have been referred to the Royal Brompton Hospital will be selected by the clinical care team. The chief investigator will divide patients into two groups: one group containing those patients who have shown worsening disease on followup imaging and another group containing those patients whose disease improves or resolves on subsequent imaging.
Retrospective analysis of each patient's baseline HRCT will be performed by Radiologists, who will be blinded to the outcomes. Radiologists will record the presence or absence of specific HRCT features that we hypothesize may be linked with a poor prognosis.
Once all studies have been reviewed, data analysis will be performed using statistical software, with a view to confirming whether some features are more frequently found on the initial scan of patients who go on to do badly. In this regard, we aim to identify features on HRCT that may be markers of poor prognosis and compare them with other clinical features.
REC name
N/A
REC reference
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