Optimising Management of Serial and Diffuse Coronary Artery Disease

• Research type

  Research Study

• Full title

  Optimising Management of Serial and Diffuse Coronary Artery Disease

• IRAS ID

  191294

• Contact name

  Divaka Perera

• Sponsor organisation

  Kings College London

• Duration of Study in the UK

  2 years, 10 months, 6 days

• Research summary

  Angina results from narrowing of heart arteries, which restrict the amount of blood that can be delivered to the heart muscle. Treatment of significant narrowings (by angioplasty/stenting or bypass surgery) can relieve angina and improve the life expectancy. Individual narrowings that need treatment are usually identified by making an educated guess of the effect that each will have on blood flow, based on the appearance of the artery on angiography (an invasive x-ray procedure which involves injecting dye into each heart artery). However, we can now accurately determine the effect of a narrowing on blood flow, using a measurement called Fractional Flow Reserve (FFR), an adjunct to angiography. Treatment based on FFR yields better outcomes, but its use is restricted in patients who have multiple narrowings, in an artery, a common clinical problem. We aim to assess two novel techniques, one invasive and one non-invasive, which will allow FFR assessment to be used in such patients.

• REC name

  London - London Bridge Research Ethics Committee

• REC reference

  15/LO/2011

• Date of REC Opinion

  14 Jan 2016

• REC opinion

  Further Information Favourable Opinion