Optimisation of CMR sequences in clinical practice
Research type
Research Study
Full title
Optimisation of CMR sequences in clinical practice: Studies of clinical efficacy in patients who undergo clinically indicated MR scans
IRAS ID
126660
Contact name
Andrew Flett
Contact email
Sponsor organisation
Research and Development, Level E, Laboratory & Pathology Block, UHS NHS Trust
Research summary
Magnetic resonance imaging (MRI) uses magnetic fields and radio−frequency (RF) waves to produce images of the internal structure of the human body. A clinical examination will consist of a number of sequences of magnetic and RF pulses with each sequence producing an image or set of images. The information contained in these images depends to a large extent on the choices made when designing the imaging sequence. There are a large number of different parameters that may be changed to improve the clinical usefulness of the images.
While it may be useful in some cases to perform a dedicated clinical trial of a proposed new MRI technique, in many cases it is adequate to trial changes to existing sequences on small numbers of patients. In this way research can advance
quickly and beneficial changes can be made to clinical scan protocols in a timely fashion. This study will investigate the modification of sequences to improve their clinical value and advance research in the field of clinical MRI. To do this it will be necessary to add extra experimental sequences to the patients’ clinically−indicated scans with their informed consent.
We will ask all subjects undergoing clinically indicated cardiovascular magnetic resonance imaging for permission to
1. Use the anonomised images and image data acquired as part of the clinical assessment for research purposes.
2. Undergo additional approved MR data acquisition to optimise MR sequences(maximum 5-10 minutes extra MR scanning per patient).REC name
Yorkshire & The Humber - South Yorkshire Research Ethics Committee
REC reference
13/YH/0223
Date of REC Opinion
1 Jul 2013
REC opinion
Further Information Favourable Opinion