Optical Imaging of Oral Mucosal lesions
Research type
Research Study
Full title
Optical Imaging of Oral Mucosal lesions
IRAS ID
108302
Contact name
Farida Fortune
Contact email
Sponsor organisation
Queen Mary University of London
Research summary
Oral mucosal lesions are usually diagnosed by a doctor inspecting the mouth and looking for signs of disease. To be certain that the suspected tissue change is due to disease, a piece of the affected tissue is cut out from inside the mouth (biopsy) and examined under the microscope for signs of pathology. The doctor will only be able to make the right diagnosis if the correct area is chosen for biopsy. We have done some research which shows we can distinguish between diseased and non diseased tissue samples by how much light they reflect or absorb. Based on this ex vivo study, we have developed a fast data capturing device in-house to evaluate the feasibility for in vivo identification of disease areas prior to biopsy. This device works by capturing microscopic information of small areas (~5seconds for a 10 X 10 X 2mm volume) in the mouth which is instantly converted into a two dimensional picture of the area the doctor is “shining the torch“ in the mouth. This two dimensional picture will show patterns which could help the doctor identify the best place to take a tissue sample to look under the microscope for signs of disease.
REC name
London - Stanmore Research Ethics Committee
REC reference
13/LO/1021
Date of REC Opinion
7 Oct 2013
REC opinion
Further Information Favourable Opinion