OE-MRI for patients with CLD V1.0
Research type
Research Study
Full title
Oxygen enhanced magnetic resonance imaging for patients with chronic lung disease (CLD)
IRAS ID
318009
Contact name
John Hurst
Contact email
Sponsor organisation
UCLH/UCL Joint Research Office
Clinicaltrials.gov Identifier
Z6364106/2023/01/17 health research, UCL data protection reference number
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Chronic lung diseases (CLD) are a very common problem in the UK as reflected in the NHS Long Term Plan. Imaging plays an important role in chronic lung disease. This application, in particular, addresses Granulomatous-lymphocytic interstitial lung disease (GLILD) which is a severe non-infectious complication of common variable immunodeficiency (CVID) and associated with poor clinical outcomes. Current diagnostic recommendations in the suspicion of GLILD include chest computed tomography (CT) scan, lung function tests (PFTs), bronchoscopy and a surgical lung biopsy. Novel radiological parameters may allow early diagnosis for GLILD with limited use of lung biopsy and related risks, and will potentially enhance patients' prognosis including assessment of disease over time. Therefore, there is a need to develop a reliable radiation-free imaging technique for diagnosis and follow-up of GLILD patients (and other CLD).
Oxygen-enhanced magnetic resonance imaging (OE-MRI) is a method that has been demonstrated for imaging lung function. OE-MRI enables regional investigation of pulmonary ventilation and gas transfer across the alveolar epithelium into the bloodstream. Previous studies by Prof Parker (PI)’s former group and his collaborators have shown that OE-MRI is feasible in patients with chronic lung disease when using 1.5 T MRI scanners. Recently, his group has also demonstrated highly sensitive novel OE-MRI methods at the more challenging MRI field strength of 3 T, making OE-MRI practical for all clinical field strength MRI scanners.
This observational study aims to establish the feasibility of lung function measurement using OE-MRI in chronic lung disease, specifically including GLILD patients. In this study, ten patients with GLILD will advanced MR scans which include 100% oxygen breathing for OE-MRI. These will be related to existing clinical data including CT and lung function tests.
For future patients, this means better monitoring of long-term prognosis for GLILD, less radiation burden to the patient and more effective management of GLILD which can lead to earlier diagnosis and more effective treatment monitoring.
REC name
London - Camberwell St Giles Research Ethics Committee
REC reference
23/PR/0844
Date of REC Opinion
29 Aug 2023
REC opinion
Further Information Favourable Opinion