Ocular inflammation post COVID vaccine
Research type
Research Study
Full title
Ocular inflammatory events following COVID-19 vaccination in paediatric population: a multinational case series
IRAS ID
306842
Contact name
Ameenat Lola Solebo
Contact email
Sponsor organisation
UCL Institute of Child Health
Duration of Study in the UK
1 years, 0 months, 4 days
Research summary
Research Summary
We propose to undertake a national epidemiological study to determine the incidence, spectrum and outcome of ocular inflammatory events following administration of the COVID-19 vaccine in paediatric populations. This information is unavailable through existing ‘routine’ (health or administrative) data sources. The proposed study will use data only (ie no patient contact) collected from managing ophthalmologist.
This study is supported by the UK's Paediatric Ocular Inflammation Group, and the COVID-19 Vaccination Ocular Inflammatory Events Study Group, International Ocular Inflammation Society (IOIS), and International Uveitis Study Group (IUSG).
The COVID-19 Vaccination Ocular Inflammatory Events Study Group was formed in April 2021, including uveitis specialists from 40 centres all over the world, with the aim of collecting data regarding the spectrum and outcome of ocular inflammatory events associated with the administration of COVID-19 vaccination.
The IUSG was formed in 1978 by a small number of clinicians who shared a common interest in uveitis. Over the next almost 40 years the group has increased in size to over 100 uveitis specialists from all over the world. The IUSG comprises clinicians and researchers who are committed to stimulate, encourage, and intensify a converted effort in research and clinical management of uveitis, with the goal of developing new methods for the diagnosis, treatment, and prevention of the blinding complications of uveitis.Summary of Results
We wanted to understand how many cases of uveitis (an inflammatory eye disease that can affect vision) were linked to use of the COVID-19 vaccines.
Through this national study, we did not have any cases of uveitis starting after the vaccine reported to us over a 1 year study period.
We also joined forces with an international team of doctors and scientists - altogether, across the world, 20 cases of uveitis after the vaccine were reported. Most events were successfully treated, and all showed a good visual outcome.
REC name
West of Scotland REC 5
REC reference
22/WS/0072
Date of REC Opinion
7 Jul 2022
REC opinion
Further Information Favourable Opinion