OCTIMISE
Research type
Research Study
Full title
Optical Coherence Tomography to guIde stent placeMent durIng percutaneouS coronary intErvention
IRAS ID
136000
Contact name
Andreas Baumbach
Contact email
Sponsor organisation
U H Bristol NHS Foundation Trust
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
Coronary artery disease (CAD) and its consequences are the leading cause of morbidity and mortality in the Western World, leading to major healthcare and economic burdens. CAD is the thickening of the walls of the coronary arteries, caused by the accumulation of fatty deposits.
Percutaneous coronary intervention (PCI) is a routine and widely used treatment to reopen narrowed or blocked coronary arteries. PCI is usually performed by feeding a hollow wire (catheter) through the blood vessels to the site of the blockage, inflating a balloon at the tip of the catheter to stretch the artery wall vessel and then placing an expandable metal tube (stent) at the site of the blockage. The stent stays in the wall of the artery in order to keep the artery wall stretched and allow blood to flow freely through the artery.Tools that can take pictures of the inside of the coronary arteries, have contributed substantially to our understanding of the how best to place a stent. Optical coherence technology (OCT) is a method for taking pictures of the inside of the coronary arteries, which provides an image with much greater resolution than current alternatives (e.g. intravascular ultrasound). The definition of the OCT images is at least ten times greater than with ultrasound, which enables very detailed imaging of the artery wall, the fatty deposits and, once placed, the stent. To date, there have been no studies of the usefulness of OCT for improving stent placement and the effectiveness of PCI. In this study we wish to assess whether routine use of OCT to guide stent placement will lead to improved stent placement. The research will involve 128 patients at up to four UK hospitals.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
15/WM/0075
Date of REC Opinion
3 Mar 2015
REC opinion
Favourable Opinion