Obesity, inflammation and the effect of bariatric surgery

• Research type

  Research Database

• IRAS ID

  269749

• Research summary

  Obesity, inflammation and the effect of bariatric surgery

• REC name

  London - South East Research Ethics Committee

• REC reference

  19/LO/1416

• Date of REC Opinion

  20 Sep 2019

• REC opinion

  Favourable Opinion

• Data collection arrangements

  This study aims to evaluate the relationship between obesity and inflammation and assess the impact of bariatric surgery on these parameters. The study population of this research project includes patients who have undergone a bariatric procedure at either Whittington Health NHS Trust or North Bristol NHS Trust. The data included in the study are: demographic, preoperative, operative data, post-operative data, pathology, weight, and follow up data.
  All identifiable information will be anonymised prior to storage in password-locked NHS computers. Only members of
  the research team will have access to these stored data.

• Research programme

  This study will use the data generated from this research database to evaluate the relationship between obesity and inflammation and assess the impact of bariatric surgery on these parameters. We will retrospectively review inflammatory markers in obese patients who have undergone bariatric surgery and assess if this level of inflammation is then influenced by the bariatric procedure and resultant weight loss. Evidence exists that maintenance of skeletal muscle and a normal body mass index (BMI) leads to a better outcome and prognosis in colorectal cancer. The data collated for the research database will be further analysed to investigate changes in inflammation associated with weight loss. Addressing the body’s inflammatory response to illness is thought to key in tackling muscle wasting. Therefore, by looking at ways of tackling obesity and inflammation we hope to transfer this knowledge to the management of obese patients with colorectal cancer.

• Research database title

  Obesity, inflammation and the effect of bariatric surgery

• Establishment organisation

  London North West University Healthcare NHS Trust

• Establishment organisation address

  St Mark's Hospital, Watford Road

  Harrow

  London

  HA13UJ