Nutrikinetics of dietary antioxidants in volunteers
Research type
Research Study
Full title
Nutrikinetics and physiological effects of dietary antioxidants of different functional foods and beverages in volunteers.
IRAS ID
195031
Contact name
Ivan Petyaev
Contact email
Sponsor organisation
Lycotec Ltd
ISRCTN Number
ISRCTN89815519
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
It is now well established that consumption of specific foods and food ingredients can be associated with considerable health benefits. The potential effect of targeted nutritional interventions can be enormous in managing such major public health problems as obesity, diabetes, cardiovascular disease and cancer. Nevertheless, it is clear that appropriately designed functional foods need to be developed first.
The planned study primarily addresses questions related to the nutrikinetics characterising long-term repeated application of health-promoting food components, where the dynamics of the release of nutrients from the food and their transformation in the digestive tract to be incorporated into the human body will be evaluated. This research project will evaluate the nutrikinetics of a range of dietary supplements comprising carotenoids, resveratrol, flavanols and omega 3 fatty acids as well as their combinations at different doses in different food matrices, such as chocolate, butter and vegetable oil. Quantitative parameters will be assessed before supplement introduction, in the postprandial period of day 1 following first oral dose administration (with main meal), following daily administration for 1, 2, 3, 4, 6 & 8 weeks and two weeks following supplement withdrawal (week 10 – end of the study) in healthy adult volunteers.
Only healthy volunteers will take part in the planned study. The selected functional foods will be added to their normal diet in limited amounts, practically excluding any possibility of adverse effects. Blood sample collection for assessing the nutrikinetics of dietary supplements will be the only minimally invasive procedure used in this study. Non-invasive collection of samples containing exfoliated corneocytes and sebaceous gland secretions from the surface of facial skin as well as cerumen (ear-wax) and tear fluid samples for evaluating physiological effects of the functional foods on lipids associated with the skin and eye is also planned for subgroups of trial participants.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
16/EE/0079
Date of REC Opinion
8 Mar 2016
REC opinion
Unfavourable Opinion