NURTuRE:AKI ACKD cohort
Research type
Research Study
Full title
National Unified Renal Translational Research Enterprise: Acute Kidney Injury_ AKI to CKD cohort (NURTuRE:AKI ACKD cohort)
IRAS ID
343268
Contact name
Mark Thomas
Contact email
Sponsor organisation
University Hospitals Birmingham NHS Trust
Duration of Study in the UK
3 years, 0 months, 0 days
Research summary
Acute Kidney Injury (AKI), defined as a severe drop in kidney function, is a major complication within the hospital setting occurring in around 20% of hospital admissions. In addition AKI is a major cause of morbidity in the short-term and where the initial injury is survived often patients fail to regain full kidney function and instead continue to lose kidney function over time, developing chronic kidney disease (CKD). Patients with CKD are then more likely to require multiple hospitalisations and may potentially require debilitating renal replacement therapies such as dialysis or transplantation. Currently there is no reliable way to know which AKI patients will progress to long term CKD, and which will recover fully.
This study, which falls under the umbrella NURTuRE:AKI biobank, seeks to collect and analyse blood and urine samples along with long-term follow up clinical data from AKI patients in order to find new biomarkers which might help to better inform clinicians as to which AKI patients are likely to recover compared to those who will progress to CKD. By finding such biomarkers we may gain insight into the pathological mechanism of AKI to CKD progression, allowing for not only better prognosis but also opening the door to new treatments to target these mechanisms and push the kidney to recover rather than continuing to lose kidney function.
In addition, to further bolster the depth of analysis available, the project, in certain recruiting centres, seeks to collect continuous blood pressure data via a wearable device, kidney biopsy samples and MRI (Magnetic Resonance Imaging) images from these patients in a number of sub-studies. Each of these additional collections forms a separate sub-study designed to increase the range of data available and further improve clinical knowledge, biomarker discovery and potential treatments. Participation in these studies is optional and is consented separately.
REC name
East of England - Cambridge East Research Ethics Committee
REC reference
24/EE/0255
Date of REC Opinion
17 Dec 2024
REC opinion
Further Information Favourable Opinion