NURTuRE AKI _ Paediatric CS
Research type
Research Study
Full title
National Unified Renal Translational Research Enterprise (NURTuRE) - Acute Kidney Injury (AKI) Paediatric Cardiac Surgery
IRAS ID
340833
Contact name
Kay Sarah Tyerman
Contact email
Sponsor organisation
Leeds Teaching HOSPITALS NHS Trust
Clinicaltrials.gov Identifier
awaited, www.biobankinguk.org
Duration of Study in the UK
24 years, 0 months, 0 days
Research summary
Between 40-50% of children, born with heart disease, who require corrective heart bypass surgery experience a decline in their kidney function. This decline in kidney function is called acute kidney injury (AKI). Some children(2-4%) who develop AKI will need dialysis to clean the blood of toxins and remove extra fluid in the first few days following surgery which can lead to prolonged admission to intensive care and hospital. Most children with AKI will appear to make a full recovery but long-term follow-up indicates that up to 17% of these children have signs of chronic kidney disease (CKD). At present it is difficult to predict which children undergoing heart bypass surgery will go on to develop AKI requiring dialysis treatment and which children will develop CKD. The aim of this study is to find out how many children develop AKI and help understand why some children recover well and others go on to develop chronic kidney disease. The findings of the study will help identify children who are more at risk of developing AKI and thereby help develop new treatments to both prevent AKI and help children who get AKI make a full recovery.
The study will involve collection of anonymised clinical information plus blood and urine samples from 150 children undergoing heart by-pass surgery. These blood and urine samples will be kept in a biobank and investigated through molecular biology(omic) tests to help find new pathways and markers that predict risk of developing AKI after heart bypass surgery. These discoveries may then in the future lead on to the development of new drug treatments to both prevent and/or treat AKI, thereby preventing CKD in this group of patients. Increased understanding in to the mechanisms of developing AKI following heart surgery may also be applicable to any cause of AKI.
REC name
East of Scotland Research Ethics Service REC 2
REC reference
24/ES/0057
Date of REC Opinion
1 Oct 2024
REC opinion
Further Information Favourable Opinion