Novel CVL designs for HD in children - Version 1
Research type
Research Study
Full title
A multidisciplinary, data-driven approach to overcome current limitations of central venous lines for haemodialysis in children and test novel solutions
IRAS ID
312540
Contact name
Rukshana Shroff
Contact email
Sponsor organisation
Great Ormond Street Hospital for Children NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 27 days
Research summary
Background: Central venous lines (CVLs) used for dialysis access in children are associated with a high complication rate leading to inadequate dialysis and often resulting in hospitalisations and multiple operations to replace failing CVLs. This can damage the child’s vessels and impair their quality of life. Currently, paediatric lines are miniaturisation of adult models without any specific attention to differences in the child’s anatomy or conditions which are not taken into account in the CVL testing phase. This causes a lack of prediction of the mechanical complications often recorded in clinics.
Aims: To identify distinctive anatomical aspects of different CVL designs and correlate them with complications and outcomes on dialysis using a multidisciplinary clinical and bioengineering approach.
Plan of Investigation: A multidisciplinary approach which brings together clinical and bioengineering expertise will be used.
We will use a multidisciplinary approach as follows:
1. Collect clinical data about CVLs' complications from four paediatric dialysis units in the UK.
2. Take high-resolution CT scan pictures of CVLs that are removed due to complications and then perform histology on the CVL to look for the position, size and types of blood clots.Outcomes: The results of this study will provide an in-depth understanding of CVL design-related complications. These data may help to improve the efficacy and safety of haemodialysis, making dialysis safe and more tolerable for children living with kidney disease.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
23/EE/0170
Date of REC Opinion
18 Jan 2024
REC opinion
Further Information Favourable Opinion