Novel 2019 Coronavirus (2019-NCOV) Pneumonia CT Manifestations [COVID-19]
Research type
Research Study
Full title
A feasibility study to inform further research into the role of radiology tests in the management and diagnosis of Novel 2019 Coronavirus (2019-NCOV)
IRAS ID
282408
Contact name
Fiona Smith
Contact email
Sponsor organisation
West Hertfordshire Hospitals NHS Trust
Duration of Study in the UK
0 years, 4 months, 0 days
Research summary
Imaging, especially CT scan has been an important imaging modality in the early diagnosis ,management and prognosis of patients with coronavirus disease, in some cases even more sensitive and accurate from PCR or swab tests. The most common CT features reported in COVID-19 pneumonia are bilateral and subpleural areas of ground-glass opacification, consolidation affecting mainly the lower lobes. There are some morphological differences in terms of the distribution of the Ground Glass pacification (GGO) and consolidation according to a study published this month\n\nThis study is looking to analyse retrospective data, including CT scans and X-rays, from all patients with suspected or confirmed COVID-19 that had a scan at West Hertforedshire Hospitals NHS Trust between the dates of 1st February 2020 and 1st April 2020. Based on case reviews, the investigators think they may have observed a manifestation of the disease visible in scans that hasn’t been observed in other publications. If this can be confirmed it would contribute to the wider knowledge of how this disease manifests and whether this can enhance diagnosis or management. Additionally they hope to look into lesion distribution and morphological features of the lesions like density (GGO, consolidations, or both) laterality, shape ( patchy / nodular), margins ( well defined or ill defined), predilection of particular locations / lobes or segments, air bronchograms, cavity, reverse halo sign and associated other findings ( like pleural effusions, pleural lesion) to understand more about the manifestations of this disease.
REC name
East Midlands - Derby Research Ethics Committee
REC reference
20/EM/0132
Date of REC Opinion
5 May 2020
REC opinion
Further Information Favourable Opinion