Nottingham Osteoarthritis Biomarker Follow Up Study

• Research type

  Research Study

• Full title

  Nottingham Osteoarthritis Biomarker Study – Follow-up

• IRAS ID

  141338

• Contact name

  Michael Doherty

• Contact email

  michael.doherty@nottingham.ac.uk

• Sponsor organisation

  University of Nottingham

• Research summary

  Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population , and its prevalence is expected to climb as the age of the population increases [http://www.who.int/chp/topics/rheumatic/en/].
  A hindrance to developing disease modifying drugs has been the inability to identify individuals who will rapidly progress towards severe disease. The use of cartilage-derived biomarkers to examine direct processes of cartilage degradation and synthesis are increasingly being used to examine clinically relevant aspects of knee osteoarthritis. A pilot study on metabolites derived from arachidonic acid in serum and synovial fluid identified some metabolites in this pathway to be significantly associated with a decreased prevalence of knee osteoarthritis after adjustment for confounders (odds ratio = 0.33 95%CI 0.13-0.82 p< 0.017). The aim of the current study is to assess the prognostic value of this metabolite by assessing its role in progression and incidence of knee osteoarthritis

  The study involves obtaining an up-to-date X-ray, pain assessment and blood and urine samples in individuals who participated in the initial Nottingham Osteoarthritis Biomarker Study (2012) as well as the Nottingham Osteoarthritis and Gout Biomarker Study (2008/2009).

• REC name

  East Midlands - Nottingham 1 Research Ethics Committee

• REC reference

  14/EM/0013

• Date of REC Opinion

  24 Jan 2014

• REC opinion

  Favourable Opinion