Normal MR Signal Reference Ranges for Paediatric Bone Marrow
Research type
Research Study
Full title
Normal MR Signal Reference Ranges for Paediatric Bone Marrow
IRAS ID
144831
Contact name
Andoni Toms
Contact email
Sponsor organisation
Research and development Office
Research summary
There is a well recognised evolution in the histology of bone marrow in children. In the neonatal period bone marrow is predominantly hematopoietic. In late adolescence the bone marrow comprises mostly yellow fat. In between, there is a transition from one to the other through various recognised geographical patterns made up of the two tissue types. This is reflected in changing MR imaging characteristics.
Unfortunately the current knowledge base has several weaknesses that may explain our anecdotal observations that the published descriptions of normal MR signal characteristics for paediatric bone marrow do not reflect our observations. An understanding of the normal appearance for any given age group is important in order to be able to identify marrow disorders such as leukaemia.
This is a retrospective study to look at the evolution of signal characteristics of bone marrow in children from 0 years to 16 years.
We aim to determine:
Normal reference ranges for spinal bone marrow characterising the changes that take place in the paediatric spine from birth to adulthood (0 years to 16 years).REC name
West Midlands - Black Country Research Ethics Committee
REC reference
14/WM/0183
Date of REC Opinion
23 May 2014
REC opinion
Favourable Opinion