Non-Invasive Ventilation For Airway Clearance in Adult Cystic Fibrosis
Research type
Research Study
Full title
Non-Invasive Ventilation (NIV) For Positive Pressure Support. A randomised cross-over trial to evaluate the short-term effects of NIV as an adjunct to airway clearance techniques in adults with cystic fibrosis.
IRAS ID
113152
Contact name
Gemma Stanford
Contact email
Research summary
Airway clearance techniques (ACTs) are an integral part of cystic fibrosis care, ensuring clearance of sputum from the lungs. With advancing disease or infections, often the effectiveness of ACTs can decrease due to patient fatigue, shortness of breath or an overwhelming amount of secretions. At this time it is necessary to re-assess ACTs and the addition of positive pressure to airway clearance techniques has been shown to decrease patient fatigue and respiratory rates during clearance. We aim to investigate the effect of the addition of non-invasive ventilation as a form of postive pressure to an established airway clearance regime during an inpatient stay for an infective excarbation of cystic fibrosis. We plan to use a randromised cross-over method to compare a standard airway clearance regime with the same regime including non-invasive ventilation and assess if there are differences between amount of sputum cleared and measures of fatigue and patient satisfaction.
REC name
London - Chelsea Research Ethics Committee
REC reference
13/LO/0565
Date of REC Opinion
29 May 2013
REC opinion
Favourable Opinion