Non-invasive ventilation for acute exacerbations in adult CF

• Research type

  Research Study

• Full title

  A mixed methods study comparing the clinical efficacy with the patient experience of non-invasive ventilation during an acute exacerbation complicated by respiratory failure in adult Cystic Fibrosis.

• IRAS ID

  126561

• Contact name

  Susan C Johnson

• Contact email

  suejohnson5@compuserve.com

• Sponsor organisation

  Manchester Metropolitan University

• Research summary

  Cystic Fibrosis (CF) is a life limiting illness. Median predicted UK survival is 41.4 years (UK CF Registry 2011). The commonest cause of death is respiratory failure.

  Non invasive ventilation (NIV) is a system which delivers a pre-set pressure to supplement the size and depth of each breath. It is introduced in CF to manage established respiratory failure. A nose or a mask which covers both the nose and mouth allows flexible ventilation, is used just at night, or for part of the day in addition or for 24 hours as clinical status indicates. It is introduced within a normal ward environment and then continued long-term at home.

  Once respiratory failure is established long-term non-invasive ventilation is introduced throughout 24 hours and multidisciplinary assessment concludes that the timing is appropriate for the individual.

  This study aims to evaluate a potential development of current practice: the use of non invasive ventilation during hospital admission only to enhance recovery from an acute exacerbation which has caused respiratory failure in those individuals where long term non invasive ventilation is not yet indicated. A mixed methods design will allow description of the experience of non-invasive ventilation during a semi-structured interview to add to understanding of the results from an experiment designed to measure the differences between non-invasive ventilation and standard care.
  Aim: To compare the clinical efficacy with the patient experience of NIV on recovery from an acute respiratory exacerbation complicated by respiratory failure in adult Cystic Fibrosis

• REC name

  North West - Preston Research Ethics Committee

• REC reference

  14/NW/0022

• Date of REC Opinion

  27 Mar 2014

• REC opinion

  Further Information Favourable Opinion