Non-invasive determination of left ventricular pressure
Research type
Research Study
Full title
Validation of non invasive measurement of central systolic blood pressure during diagnostic cardiac catherterisation and cardiac MRI
IRAS ID
135621
Contact name
Philip Chowienczyk
Contact email
Sponsor organisation
King's College London
Research summary
Modern imaging methods provide high resolution dynamic measures of cardiac dimensions. To exploit these to the full to understand heart disease, they need to be combined with measures of pressure within the heart chambers. This then allows fundamental mechanical properties of the heart like left ventricular wall stress and cardiac work to be calculated. The purpose of this study is to validate a non-invasive method for estimating pressure in the main pumping chamber of the heart – the left ventricle.
This will be done in patients who are having a routine clinical catheter either with or without magnetic resonance imaging (MRI). During a routine clinical catheter a hollow fluid filled catheter is placed in the aorta and in the left ventricle. In addition to the routinely gathered clinical data, participants agreeing to the research will have more detailed measures of pressure performed using a pressure sensing wire introduced inside the hollow catheter. Additional measurements of flow in the carotid arteries/aorta will be made using MRI or (in patients not having an MRI) by ultrasound. These additional measurements will add approximately fifteen minutes to the total procedure time.
Blood pressure in the upper arm will be estimated non-invasively from a cuff placed on the upper arm, using the usual procedure but with modified analysis of pressure in the cuff.
This data will be used to help validate a mathematical algorithm to non-invasively estimate the pressure in the ventricle and aorta from the aortic flow measurements and the upper arm blood pressure measurements.
REC name
London - London Bridge Research Ethics Committee
REC reference
14/LO/0094
Date of REC Opinion
2 Apr 2014
REC opinion
Further Information Favourable Opinion