NON-INTERVENTIONAL CLINICAL RESEARCH STUDY CYT-DEM-01
Research type
Research Study
Full title
An Open Recruitment, Case Controlled, Multicentre, Observational Research, Study to Assess the Functional Integrity of the Mammalian Target of Rapamycin (mTOR) Pathway in the Peripheral Lymphocytes of Subjects Diagnosed with Probable Alzheimer’s Disease (AD), Fronto-Temporal Lobe Dementia (FTLD) or Lewy Body Dementia (LBD) and Compared with Cognitively Normal Controls
IRAS ID
143039
Contact name
Vanya Johnson
Contact email
Sponsor organisation
Cytox Ltd
Research summary
This is a non-interventional research study looking at the role of a biochemical signalling pathway in blood cells in the development of dementia.
The basis of the research is the the detection of a lack of regulation of a specific protein, known as the mammalian target of rapamycin (or mTOR), which controls cell growth, division and survival. The detection of this deregulation i.e. lack of control of mTOR may act as an indicator or early risk factor in the development of dementia. It is possible to look at this mTOR function in a person’s blood.
This research study aims to help clarify the relationship between the deregulation of mTOR and the different types of dementia (Alzheimer Disease, Fronto-Temporal Lobe Dementia and Lewy Body Dementia), in comparison to blood cells from people who do not have dementia.
REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
14/WM/0023
Date of REC Opinion
10 Feb 2014
REC opinion
Favourable Opinion