NOMAD study
Research type
Research Study
Full title
Non-invasive and minimally invasive tools to optimise management of atopic dermatitis
IRAS ID
330915
Contact name
Michael Ardern-Jones
Contact email
Sponsor organisation
University Hospitals Southampton NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 0 days
Research summary
Atopic dermatitis (AD) is a common disorder of the skin characterised by skin inflammation. This project’s primary aim is to utilise technology to measure changes in skin physiology to define biomarkers appropriate for (i) personalised medicine (predicting response to treatment) and (ii) early indication of treatment responders. Importantly, this project focuses on minimally invasive and non-invasive measures which will offer realistic potential for clinical use. This work will greatly benefit patients with atopic dermatitis as it will facilitate getting the right treatment to patients first time. Similarly, by defining clinical markers which accurately predict response to treatment before clinical changes become evident, this approach will facilitate early change of treatment to more effective therapies, and also benefit society by avoiding wasted expense on costly medicines. As a consequence of the design of this project the primary focus will be on individuals with moderate/severe atopic dermatitis, although it is expected that these findings will in turn benefit the wider population with atopic dermatitis. To the individuals with atopic dermatitis, finding an effective treatment more quickly is a very significant benefit because the burden of atopic dermatitis on quality of life is high and is more than for other severe skin diseases.
REC name
London - Dulwich Research Ethics Committee
REC reference
23/PR/1301
Date of REC Opinion
16 Nov 2023
REC opinion
Further Information Favourable Opinion