NOAH: development project
Research type
Research Study
Full title
Neurological Observations Assistant in Healthcare (NOAH): development project
IRAS ID
251774
Contact name
Paul Bentley
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust, Joint Research Compliance Office
Clinicaltrials.gov Identifier
P70144, NIHR BRC ITMAT ; P59933 , NIHR Grant
Duration of Study in the UK
4 years, 0 months, 1 days
Research summary
DESIGN: data science observational study investigating relationships between behaviour, neurological observations, and general systemic health, across a range of medical disorders.
AIMS: to explore mathematical relationships between movements / physiological data and consciousness / physical disability, in neurological and general medical populations.
OBJECTIVES: to develop a statistical or machine–learning model relating data from movement sensors (supplemented with physiological sensors), and: 1)performance of natural activities; 2)absolute values and short-term changes in neurological observations (motor, functional, consciousness); 3)and long-term motor functional outcomes at 4, 8 and 12 weeks post baseline.
POPULATION: 400 patients with neurological syndromes and 50 controls without neurological syndromes. 50 patients without neurological syndromes admitted to Guy’s and St Thomas’(GST).
MEASURES: 1) baseline assessments 2)video recording of participant behaviours on the hospital ward to act as ground-truth; 3)neurological assessments of motor function and consciousness; 4)movement recordings using wearable sensors; 5) limb monitoring questionnaire; 6) motor and consciousness clinical scores and baseline information from medical records. Only for participants recruited at CXH additional: 7) follow-up functional assessments of long-term recovery; 8) brain imaging; 9)(for subset of 50 participants) electroencephalogram using wearable sensors; and (for subset of 20 participants) movement recordings using wearable sensors and functional assessment in the community.
DURATION: 4 years in total. Study duration per-participant recruited at CXH will be 1-28 days (or earlier dependent on hospital discharge), with a telephone follow up at 4, 8 and 12 weeks post baseline. A subset of 20 participants will be provided with sensors on hospital discharge for 1-30 days. Study duration per-participant recruited at GST will be 2 days.
REC name
London - Queen Square Research Ethics Committee
REC reference
20/LO/0172
Date of REC Opinion
7 May 2020
REC opinion
Further Information Favourable Opinion