NIRS in moyamoya syndrome
Research type
Research Study
Full title
Near infrared spectroscopic assessment of paediatric Moyamoya syndrome.
IRAS ID
212831
Contact name
Martin Tisdall
Contact email
Sponsor organisation
Great Ormond Street Hospital NHS Foundation Trust
Duration of Study in the UK
0 years, 11 months, 30 days
Research summary
Near infrared spectroscopy (NIRS) is an established technique that allows non-invasive measurements oxygen levels and blood flow within the brain. It is therefore an ideal way to monitor and investigate children neurovascular disease. NIRS is particularly applicable to children as their thin scalp and skull allow improved review of structures within the brain. NIRS has become routine clinical practice in some areas of paediatric care. \nIn this pilot we will examine the feasibility and telerability of NIRS measurements of oxygenation and blood flow in children with moyamoya syndrome. Patients with moyamoya syndrome have inadequate blood supply to the brain and therefore reduced ability to regulate constant blood flow in (autoregulation). We hypothesise that in this patient group NIRS is able to detect this impaired autoregulation (the body’s ability to self-regulate), and therefore guide management strategies. However, before we can explore this hypothesis we need to establish that NIRS is feasible and well tolerated in the patient group.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
16/LO/2065
Date of REC Opinion
29 Mar 2017
REC opinion
Further Information Favourable Opinion