NewDAWN version 1.0
Research type
Research Study
Full title
New remission care pathway: Diabetes Adaptive Weight management Network
IRAS ID
324924
Contact name
Susan Jebb
Contact email
Sponsor organisation
University of Oxford
ISRCTN Number
ISRCTN00043802
Duration of Study in the UK
20 years, 10 months, 30 days
Research summary
For people with type 2 diabetes (T2D) who are overweight, losing weight can put diabetes into remission (meaning normal blood glucose levels without needing medication). NHS England is piloting this approach using an intensive weight loss programme. Early evidence shows that not every patient is willing to try this programme, and while some may succeed, others find the diet unsuitable. Currently no other weight loss programme aiming for remission is offered. Together with patients and stakeholders, we have created a new care service (NewDAWN) for people with T2D that supports people to find a diet which is suitable and effective.
We will test the new service in a randomised controlled trial, against the standard NHS programme (current best care). We will recruit 150 people to an internal pilot trial and over 16 weeks we will assess how well the programme works, including feedback from healthcare practitioners and participants. If indicated, we will make tweaks to the service to improve it. If the trial meets pre-specified criteria for success, we will proceed to a full trial (n=1788 in total) to test whether the new service can increase the rate of remission of T2D compared with current best care after 1 year. We will measure the effect of the intervention on cardiovascular risk and quality of life and assess whether the new pathway would save the NHS money compared to current care.
We will study the new service carefully throughout, including audio recording conversations between the NewDAWN staff and patients, and interviewing clinicians and patients to understand which parts of the new service work well and which could be improved if the service was to be adopted by the NHS.
If it is cost-effective, our final step will be to prepare materials and identify practices to support implementation within the NHS.REC name
South Central - Oxford B Research Ethics Committee
REC reference
23/SC/0230
Date of REC Opinion
14 Aug 2023
REC opinion
Further Information Favourable Opinion