New Test for Nicotine Levels at Birth
Research type
Research Study
Full title
A prospective pilot study investigating the relationship between prenatal nicotine exposure and amniotic fluid cotinine levels at birth.
IRAS ID
335436
Contact name
Artur Abelian
Contact email
Sponsor organisation
BCU R&D
Duration of Study in the UK
0 years, 5 months, 30 days
Research summary
Nicotine, a potent vasoconstrictor, has consistently been shown to harm foetuses when pregnant women use nicotine-containing products, leading to reduced blood flow and numerous adverse outcomes for neonates (newborns) such as low birth weight, preterm birth, respiratory issues, and an increased risk of sudden infant death syndrome.
We aim to conduct a study to explore the relationship between self-reported nicotine exposure during pregnancy and the concentration of cotinine (a nicotine metabolite)in amniotic fluid at the time of birth. The hope is that by measuring cotinine levels in amniotic fluid, this research could reveal the extent of foetal nicotine exposure and identify children in need of extra support.
We will recruit 45 pregnant women, encompassing individuals with varying degrees of nicotine exposure. If they meet the eligibility criteria and provide consent, we will obtain a history of nicotine exposure from 20 weeks gestation onwards (this will include cigarettes, vapes, nicotine patches, as well as any passive exposure, until the time of birth. Upon childbirth, a small sample of amniotic fluid will be collected and sent for cotinine measurements, involving analysis through liquid chromatography and mass spectrometry in Professor Keevil's laboratory at Wythenshawe Hospital.
This approach serves as a foundation for subsequent investigations that can delve deeper into the findings and contribute to the development of specialised medical protocols for newborns with nicotine exposure.
REC name
London - Hampstead Research Ethics Committee
REC reference
24/PR/0189
Date of REC Opinion
15 Apr 2024
REC opinion
Further Information Favourable Opinion