New radiological classification for pulmonary embolism - Version 1
Research type
Research Study
Full title
A new combined radiological and clinical classification for pulmonary embolism using computed tomography pulmonary angiography.
IRAS ID
163208
Contact name
Rachel Chubsey
Contact email
Sponsor organisation
Keele University
Clinicaltrials.gov Identifier
14/YH1270,
Duration of Study in the UK
0 years, 6 months, 30 days
Research summary
Due to the difficult diagnosis and subsequent management of pulmonary embolism(PE), (which is a blood clot found in the blood vessels of the lungs), there is a need for clearer classification of the disease on radiological imaging. I propose to research and create a new classification system for pulmonary embolism (PE), diagnosed on computed tomography pulmonary angiography (CTPA). A CTPA is a scan which looks in detail at the blood vessels in the thorax to determine the presence of clot. The aim is for the classification system to show a relationship with the patient’s immediate clinical presentation which can subsequently be used to direct treatment.
A group of 50-100 patients who were diagnosed with a PE on CTPA, at the Royal Stoke University Hospital will be collected. A search of the radiology database CRIS will be conducted and those patients with a massive pulmonary embolism will be included, provided they fit the strict inclusion and exclusion criteria. The radiology images, reports and patient notes of the selected group will be anonymised and data collected. Once analysed a new classification will be created from the images taken and any other relevant patient investigations such as, heart rate, blood pressure, biochemical markers and electrocardiograph findings. This will allow a holistic approach to be taken when creating the criteria ensuring many aspects of the patients' presentation and clinical state are included.
The aim is for the new classification to be fit for use in clinical practice and to aid the direction of patient treatment and follow up long term.REC name
Yorkshire & The Humber - Bradford Leeds Research Ethics Committee
REC reference
14/YH/1270
Date of REC Opinion
28 Nov 2014
REC opinion
Favourable Opinion