Neutrophil activity using Sysmex XN technology in sickle cell disease
Research type
Research Study
Full title
Can assessing neutrophil activity using Sysmex XN technology in sickle cell patients aid earlier identification of crisis?
IRAS ID
263562
Contact name
Satyajit Sahu
Contact email
Sponsor organisation
Lewisham and Greenwich NHS Trust
Duration of Study in the UK
0 years, 0 months, 21 days
Research summary
The study is about complications that occur in an inherited haemoglobin disorder called sickle cell disease, where a defective haemoglobin S gene is inherited from your parents. This disease causes the red blood cells that carry oxygen to change shape to ‘sickled cells’, which then stick to other cells such as neutrophils and block blood vessels and starve the tissues of oxygen causing pain known as ‘crisis.’ Current treatment only reduces the amount of crises caused by sickle cells, not stopping them completely. This study aims to identify ways of detecting the activity of neutrophils using a routine blood test, which could show how likely the patient is to suffer crisis. This would allow clinicians to identify early signs of crisis, allowing earlier intervention and treatment, reducing hospital admissions and ultimately better patient experience (with less pain and discomfort.)
REC name
N/A
REC reference
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