Neuropathic symptoms in idiopathic Parkinson’s Disease
Research type
Research Study
Full title
An investigation of the prevalence and the determinants of neuropathic symptoms in idiopathic Parkinson’s disease
IRAS ID
220562
Contact name
Panagiotis Zis
Contact email
Sponsor organisation
Sheffield Teaching Hospitals NHS FT
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Symptoms of pain in Parkinson’s disease are frequently reported. A link between damaged nerves (peripheral neuropathy) and Parkinson’s disease has been demonstrated in some rare genetic forms of Parkinson’s disease, such as in patients with gene mutations. No large scale study assessing the presence and the nature of pain caused by damaged nerves (neuropathic symptoms) has been conducted in idiopathic Parkinson’s disease.
Robust data on damaged nerves (polyneuropathies) of any cause are lacking. Very few studies have accurately assessed the commonness of damaged/diseased nerves in the general population. The current estimates are between 2.4 % and 8.0 %. Damaged or diseased nerves (Peripheral neuropathy) is reported in Idiopathic Parkinson’s disease in up to 55% of the patients.
The primary aim of our study is to estimate the prevalence of chronic pain (neuropathic symptoms) and damaged or diseased nerves (peripheral neuropathy) in a cohort of patients with idiopathic Parkinson’s disease and compare it with the commnoness of such symptoms in a group of volunteers not suffering from Parkinson’s disease. A secondary aim of our study is to determine how the presence of pain affects the patients’ quality of life.
REC name
London - Westminster Research Ethics Committee
REC reference
17/LO/0336
Date of REC Opinion
28 Feb 2017
REC opinion
Favourable Opinion