Neonatal Resuscitation - Sustained Inflations
Research type
Research Study
Full title
Comparison of a sustained inflation to shorter inflation breaths during resuscitation at delivery of prematurely born infants.
IRAS ID
210610
Contact name
Anne Greenough
Contact email
Sponsor organisation
King's College London
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Approximately 10% of babies will require some respiratory support at delivery; the need for resuscitation increasing as gestational age at birth decreases. The best way to resuscitate babies at delivery is not known, and hence there are several techniques in common practice. The main difference between these techniques is the length of the first mechanical inflations (or ‘breaths’) given to babies. We are interested in how effective a long first breath, or ‘sustained inflation’ is compared to repeated shorter breaths in the resuscitation of prematurely-born infants after birth.
Eligible infants are those born at less than 34 weeks requiring resuscitation at delivery, providing that there are no major congenital abnormalities. Infants in the study will be randomised (using a random number generator with allocations sealed in opaque envelopes) to receive either five ‘inflation breaths’ lasting 2-3 seconds, or a 15 second ‘sustained inflation’. The time it takes for a baby to start breathing for itself will be recorded, as will information about the resuscitation; including the pressures used, the amount of gas that is breathed in and out of the lungs, the heart rate, and the level of carbon dioxide. We will use this information to assess whether sustained inflations are more effective during resuscitation at delivery. We will also collect data on any adverse effects and, for example, how many babies in each group require mechanical ventilation.REC name
London - Riverside Research Ethics Committee
REC reference
16/LO/1718
Date of REC Opinion
8 Nov 2016
REC opinion
Further Information Favourable Opinion