NEON Trial, NEON-O Trial. NEON-C Trial. v1.0
Research type
Research Study
Full title
NEON (Narrative Experiences Online) study: trials of an online intervention
IRAS ID
249015
Contact name
Mike Slade
Contact email
Sponsor organisation
Nottinghamshire Healthcare NHS Foundation Trust
ISRCTN Number
ISRCTN11152837
Duration of Study in the UK
2 years, 5 months, 27 days
Research summary
This study consist of three pragmatic randomised controlled trials (RCTs) of the NEON Intervention, a web-site providing access to the NEON Collection of mental health recovery narratives. All study procedures are conducted online.
The trials are as follows:
NEON Trial: a definitive trial of the use of the NEON Intervention to support people with experience of psychosis and current experience of mental health distress.
NEON-O trial: an exploratory trial of the use of the NEON Intervention to support people with experience of other (non-psychosis) mental health problems and current experience of mental health distress
NEON-C trial: an exploratory trial of the use of the NEON Intervention to support people who have acted as informal carers for people with experience of mental health problems
Lay Summary and research Summary of results
https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbeWQC6Pua4fPnw5ajwjck-2FFad3qlnO2AT36zohXC-2F-2BP-2FKClbBegJqc-2BCoEqi5PwjeQ-3D-3DrUht_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhguotbYFnfjl0omu6lnEGKdo2kOymsXueUawHcA7Vy-2FhGO-2F4XmGvOGDfx3b9f8qv7VVVzsqWCQ3hgBFvkIFYfRzar67ImSDvmpG4h1VlBSFIkjei-2FAjMOBp-2FK5oAn1cTDjb034t24UQTUwvQNwOHC2Cg-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=G8TDf%2F9pO38hkWoZe0ktCBmp4rJhfeoHJCRK0Es%2BnWw%3D&reserved=0 which was subsequently updated https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbeWQC6Pua4fPnw5ajwjck-2FGesrpSv9sWGUjp8kDFpgOf3BsJlP7CvkN6Av-2FBOCv-2FZA-3D-3DC4hj_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhgOdefEDY3WWPOQLC4gWf2E1n2DbsRCjAFdryIOE-2BqhmgtibJ-2BObKHjWZmlUBNXRGb7NdRuV-2FUUQsGaI7Eh7SEn0cKMTeqIJncXsA0nSXqFjOgBHWVe-2FKTOUwmqUtD92yAwrBJ0jLFX2CzD2iDfAmKtA-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=29p1TrRBiek0aQ8y9mRXqH7TadM2BOVJ8Bxhgc4Lk70%3D&reserved=0 The NEON Trial https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbZKm4C0TeSkP8lYcMVEmwG4z1-2FdCQWLcZB35zfUxvpz848zS_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhgn-2FcidA2F5ciUZYxi1aRyjcY0gP9h7S0uZT2F7LKSWw94JrbSSUuPHcNF7WXp7zyTJoDP9T5UsQPx0IabPH8iAI8LjKwFfZl8z803NebUMU67enK-2BUaTNiNmnvM7UI70vswJLeHJsNrcHUGbsEmns1g-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=qJHYRpymwVNnF%2BnSIIRc8m2WLiMRoeLn2Kvc2E0eBHo%3D&reserved=0 and NEON-O Trial https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbZKm4C0TeSkP8lYcMVEmwG41pMngmFM0xFX9sFl324gR8Vew_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhgEB9EZYUXYy3fRnpgz0PMPLHcL5PujaLx4W7raL23fvFeCdkpKlx1mIjbFWCUd-2Fh-2BTLR6dtF3cVOn-2ByGFPWyWxiE4I-2B0bdmZ4i8daKoHZeNlGBkghLZdTcIzOe5XjsgHuPPcTMfB9Cpyq7LqL6XKELg-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=ilIyGamMdapBcLnFoMJ3sKcVONvK1CvqcPC32Sn%2FNSM%3D&reserved=0 were designed to produce definitive results. The NEON-C Trial https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbZKm4C0TeSkP8lYcMVEmwG5dBKlkBgKMeNDVblqOPfV2vaw8_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhgBsXZ58xiXUHNmqs8Q-2Bjy7W5HLANO-2FO76r9WpZiv6I9jd10UHIv3WTPfuSCUQSNEo2YcogonDE-2BhYHpnGDdRTjdTUh7LGSsTCXrILSyy-2BBCy8hMMMLVjZxlqLExwUEhIZ2Ehn2EAdsXHvMTJyIV-2BNfg-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=mbKDm2zmfJfhT%2BQOf%2Fo16uePN%2FPetZ3Umy6Cz3dyEw8%3D&reserved=0 was intended to evaluate the feasibility of a definitive trial for people who are informal carers for people affected by mental health problems.Before completing our trial analyses, we documented the cost of developing and delivering the NEON Intervention https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fu2790089.ct.sendgrid.net%2Fls%2Fclick%3Fupn%3DXv3JSvJ-2B3M71ppf7N9agbeWQC6Pua4fPnw5ajwjck-2FE-2BeJDJOki8vomTm-2BJw5SgA0jOLpW2jiOx-2F8bPB-2FeVplA-3D-3DLe35_E1aO2-2BZlVOSJJV-2FajQqskegTd6IRomHYTi-2Fbt8SH3YL7-2BDj15Vu7idtL7fDb5uhghTbWya0g-2BubdpIAsBmtglsD-2BPTJTxKvY4m0Hb-2FGmJlxYP9tO-2F-2FX2Bje2fx21sldX99iBwmpJZkzssbSrAUTFrc8Q1f9elR-2BCWjXQF7s3HxwFdlE9fgTdPmH-2BU30uoOtREeVSaDhIgQJ2a-2BzbGR-2FVgg-3D-3D&data=05%7C01%7Cleicestercentral.rec%40hra.nhs.uk%7Ce866fb2f90b04e55a70c08dbb5394f35%7C8e1f0acad87d4f20939e36243d574267%7C0%7C0%7C638303029966627282%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&sdata=fNj07A5nGWOllcDxVl%2BZl2%2F5Jw4pThB2Zp7zZFtReLQ%3D&reserved=0 to participants in the NEON Trial and NEON-O Trial. We found that the total cost per intervention arm participant was between £241 and £349. This means that the NEON Intervention is an inexpensive intervention, and the cost per participant would likely be lower if it was deployed on a larger scale.
The NEON-O Trial for people with non-psychosis mental health problems involved 1,023 people from across England, and found that the NEON Intervention was both effective, leading to higher quality of life and improved meaning in life, and cost-effective, especially for people currently using mental health services. Our findings will be reported as a paper in the journal World Psychiatry in 2024.
The NEON Trial for people who had experienced psychosis involved 739 people from across England. It found no evidence that the NEON Intervention was effective. Our findings will be submitted for publication in Autumn 2023.
The NEON-C Trial for informal carers involved 54 people from across England. It found a small effect on hope, and a moderate effect on the presence of meaning in life. Five modifications were recommended to improve the user experience, applicability, and trial processes. We have submitted our findings for publication. We conclude that a future definite trial is feasible, once those modifications have been made.
REC name
East Midlands - Leicester Central Research Ethics Committee
REC reference
19/EM/0326
Date of REC Opinion
8 Nov 2019
REC opinion
Favourable Opinion