Near Infrared Detection of Spreading Depolarisations in TBI
Research type
Research Study
Full title
Near Infrared Spectroscopy to Detect Spreading Depolarisations in Traumatic Brain Injury
IRAS ID
124060
Contact name
Mark H Wilson
Contact email
Research summary
Trauma is the commonest cause of death in the under 40s and brain injury is the commonest cause of that death. Brain Injury also has profound consequences for survivors and their loved ones. To reduce this we need to find techniques that minimise the further evolution of brain damage following injury. A process known as “Spreading Depolarisations” refers to the abnormal electrical activity within the brain that commonly occurs following brain injury. This phenomenon increases the metabolism of brain cells which, at a time when they are vulnerable, can do them harm. Currently, the only technique for detecting this electrical activity is to place invasive catheters within the brain. This study aims to detect these depolarisations using a noninvasive technique. Near Infrared light detects changes in cerebral blood flow. These depolarisations are thought to increase blood flow in their wake, hence, the “spreading depolarisations” may be detectable with near infrared light without the need for invasive monitoring. By using a “cap” of 48 of such probes placed on the patients head, we aim to demonstrate these depolarisations non invasively. Although not part of this study, medical treatments could in the future be used to reduce their presence and help preserve vulnerable brain tissue.
REC name
Yorkshire & The Humber - Leeds West Research Ethics Committee
REC reference
13/YH/0117
Date of REC Opinion
21 Jun 2013
REC opinion
Further Information Favourable Opinion