NCT & NFT Leaky Gut

  • Research type

    Research Study

  • Full title

    The effect of Bioactive compounds NCT and NFT on intestinal barrier function in participants with Irritable Bowel Syndrome with Diarrhoea

  • IRAS ID

    344580

  • Contact name

    Anthony Hobson

  • Contact email

    anthonyhobson@hotmail.com

  • Sponsor organisation

    The Functional Gut Clinic

  • Duration of Study in the UK

    0 years, 3 months, 31 days

  • Research summary

    Irritable bowel syndrome is a debilitating condition that affects around 10% of the UK population. Of those suffering, around 25% have the diarrhoea (IBS-D) variant of the condition. Several potential mechanisms have been potentially identified as a contributing factor or associated with IBS-D, one of those being increased intestinal permeability, sometimes referred to as a 'leaky gut'.

    There is currently a lack of treatment options for IBS-D and the satisfaction of sufferers if generally relatively poor. Targeting potential underlying mechanisms may help subsets of those suffering with IBS-D.

    NFT and NCT are two bioactive compounds considered a dietary/nutritional supplement, found in a range of edible sources (such as black pepper) that have been shown to elicit an effect on cell signalling pathways and reduction of intestinal permeability.

    This pilot study, aims to test whether NFT+NCT can reduce intestinal permeability and improve symptoms in patients with IBS-D compared to a placebo capsule. The study will utilise a single blind, randomised design, with a ~3 week screening period and 3 week treatment period.

    The study is first and foremost a pilot study to assess initial effect of the product on gut barrier function that could help to power a large study.

  • REC name

    London - Chelsea Research Ethics Committee

  • REC reference

    24/LO/0442

  • Date of REC Opinion

    17 Jul 2024

  • REC opinion

    Further Information Favourable Opinion