NCT & NFT Leaky Gut
Research type
Research Study
Full title
The effect of Bioactive compounds NCT and NFT on intestinal barrier function in participants with Irritable Bowel Syndrome with Diarrhoea
IRAS ID
344580
Contact name
Anthony Hobson
Contact email
Sponsor organisation
The Functional Gut Clinic
Duration of Study in the UK
0 years, 3 months, 31 days
Research summary
Irritable bowel syndrome is a debilitating condition that affects around 10% of the UK population. Of those suffering, around 25% have the diarrhoea (IBS-D) variant of the condition. Several potential mechanisms have been potentially identified as a contributing factor or associated with IBS-D, one of those being increased intestinal permeability, sometimes referred to as a 'leaky gut'.
There is currently a lack of treatment options for IBS-D and the satisfaction of sufferers if generally relatively poor. Targeting potential underlying mechanisms may help subsets of those suffering with IBS-D.
NFT and NCT are two bioactive compounds considered a dietary/nutritional supplement, found in a range of edible sources (such as black pepper) that have been shown to elicit an effect on cell signalling pathways and reduction of intestinal permeability.
This pilot study, aims to test whether NFT+NCT can reduce intestinal permeability and improve symptoms in patients with IBS-D compared to a placebo capsule. The study will utilise a single blind, randomised design, with a ~3 week screening period and 3 week treatment period.
The study is first and foremost a pilot study to assess initial effect of the product on gut barrier function that could help to power a large study.
REC name
London - Chelsea Research Ethics Committee
REC reference
24/LO/0442
Date of REC Opinion
17 Jul 2024
REC opinion
Further Information Favourable Opinion