NATURAL HISTORY DILATED CARDIOMYOPATHY ASSOCIATED WITH BAG3 MUTATIONS

• Research type

  Research Study

• Full title

  A PROSPECTIVE MULTINATIONAL STUDY OF THE NATURAL HISTORY OF PARTICIPANTS WITH BAG3 MUTATION ASSOCIATED DILATED CARDIOMYOPATHY

• IRAS ID

  316928

• Contact name

  Perry Elliott

• Contact email

  perry.elliott@ucl.ac.uk

• Sponsor organisation

  Pfizer Inc.

• Duration of Study in the UK

  1 years, 3 months, 20 days

• Research summary

  This is a natural history study in dilated cardiomyopathy associated with a particular type of mutation in the BAG3 gene. Dilated cardiomyopathy is a type of heart muscle disease that causes the heart chambers (ventricles) to thin and stretch, growing larger, and making it harder for the heart to pump blood to the rest of the body. This can cause fatigue and shortness of breath, and is a common cause of heart failure. This study will explore the natural progression of dilated cardiomyopathy caused by BAG3 gene mutations to facilitate future interventional trials.

  Participants will be asked to take part in the study for about 52 weeks and wear an Actigraph CentrePoint Insight Watch device throughout. Participants will wear an ECG patch for 1-2 weeks at home.

• REC name

  London - Bloomsbury Research Ethics Committee

• REC reference

  22/PR/0929

• Date of REC Opinion

  9 Aug 2022

• REC opinion

  Unfavourable Opinion